The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. Broncos picks, be sure to check out the NFL predictions and betting advice from the SportsLine Projection Model. Caesars Sportsbook lists Los Angeles as the 4.5-point home favorite, while the over/under, or total number of points Vegas thinks will be scored, is 45.5 in the latest Broncos vs. Meanwhile, the Chargers are 8-3 against the spread in their last 11 games versus the AFC West.

The Broncos are 12-4 against the spread in their last 16 games after scoring fewer than 15 points in their previous game. Both squads want this win badly, so we can expect a high-energy contest to close out the Week 6 NFL schedule. Nathaniel Hackett and the Denver Broncos (2-3) will battle Brandon Staley and the Los Angeles Chargers (3-2) in a primetime affair on Monday Night Football.